Pyrrolo [2,3-d] pyrimidin-4-ol 98%min

Property

Melting point: 345-348°C
Boiling point: 473.1±18.0 °C(Predicted)
Density: 1.62± 0.1g /cm3(Predicted)
RTECS: UY9440000
Storage conditions 2-8°C
Solubility: Soluble in dimethyl sulfoxide.
Appearance: White to off white solid
acidity coefficient (pKa) 11.99 + 0.20 (Predicted)
Sensitivity: Moisture & Light Brown
InChIKeyFBMZEITWVNHWJW UHFFFAOYSA - N

Safety information

Danger symbol (GHS):
Warning word: Warning
Hazard description: H317-H319
Precautions : P280-P302+P352-P305+P351+P338
Danger Class code: 36-43
Safety Instructions:26-36/37
WGK Germany : 3
Hazard Note :Irritant
HS Code: 29335990

Conditions for safe storage, including any incompatibilities

Store in a cool place. Keep the container closed and store in a dry, ventilated place.
Recommended storage temperature: 2-8 °C
Operate under nitrogen to avoid moisture. Sensitive to heat, light and moisture stored in nitrogen.

Package

Packed in 25kg /drum, lined with double plastic bag, or packed according to customer needs.

Application Fields

Intermediate, Pharmaceutical intermediate
It is a prodrug of xanthine oxidase activated thymidine phosphorylase inhibitors.
It is an organic synthesis and pharmaceutical intermediate, mainly used in the production of tofacitinib, barricitinib and other anticancer drugs in the process of chemical and pharmaceutical synthesis.

Upstream products

CAS NO.: 67831-84-9
Product Name: 4H-Pyrrolo[2,3-d]pyrimidin-4-one,1,2,3,7-tetrahydro-2-thioxo-
Molecular formula: C6H5N3OS

CAS NO.:7400-06-8
Product Name: 6-Amino-5-(2,2-diethoxyethyl)pyrimidin-4-ol
Molecular formula:C10H17N3O3

CAS NO.:52133-67-2
Product Name: Ethyl 2-cyano-4,4-diethoxybutyrate
Molecular formula: C11H19NO4

CAS NO.:7400-05-7
Product Name:4(1H)-Pyrimidinone,6-amino-5-(2,2-diethoxyethyl)-2,3-dihydro-2-thioxo-
Molecular formula:C10H17N3O3S

Down-stream products

CAS NO.:3680-69-1
Product Name:4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
Molecular formula:C6H4ClN3

CAS NO.:346599-63-1
Product Name: 4-Chloro-5H-pyrrolo[2,3-d]pyrimidin-6(7H)-one
Molecular formula:C6H4ClN3O

CAS NO.:941685-26-3
Product Name:4-chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine
Molecular formula:C12H18ClN3OSi

CAS NO.:186519-89-1
Product Name: 4-chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine
Molecular formula:C12H8ClN3O2S

Quality Specification

TESTING ITEM	SPECIFICATION
Characteristics	White to off white solid
Water Content	≤0.5%
Purity(by HPLC)	≥98.0%
Assay(by HPLC)	≥98.0%